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Symbol
Name
ID

Il4
interleukin 4
MGI:96556

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Abnormal bleeding	Epistaxis	Arterial thrombosis	Superficial thrombophlebitis	Abnormality of thrombocytes	Thrombocytopenia	Elevated erythrocyte sedimentation rate	Hepatosplenomegaly
Disease(s) Associated with IL4	Abnormal bleeding	Epistaxis	Arterial thrombosis	Superficial thrombophlebitis	Abnormality of thrombocytes	Thrombocytopenia	Elevated erythrocyte sedimentation rate	Hepatosplenomegaly
autoimmune thrombocytopenic purpura
Behcet's disease
pancreatic cancer
temporal arteritis

Mouse Phenotypes

abnormal dendritic cell differentiation

increased mast cell degranulation

abnormal thymus morphology

abnormal thymus cell ratio

thymus cortex hypoplasia

thymus hypoplasia

abnormal thymocyte activation

abnormal T cell differentiation

abnormal T-helper 2 cell differentiation

increased double-negative T cell number

decreased double-positive T cell number

decreased basophil cell number

decreased eosinophil cell number

increased eosinophil cell number

abnormal T cell number

decreased CD4-positive, alpha-beta T cell number

increased CD4-positive, alpha-beta T cell number

absent CD8-positive, alpha-beta T cells

increased CD8-positive, alpha-beta T cell number

abnormal microglial cell morphology

impaired eosinophil recruitment

abnormal mast cell physiology

increased IgA level

decreased IgE level

increased IgE level

decreased IgG1 level

increased IgG1 level

decreased IgG2a level

increased IgG2a level

increased IgG2c level

decreased IgG level

increased IgG level

decreased IgM level

abnormal T-helper 2 physiology

abnormal T cell activation

abnormal osteoclast physiology

abnormal splenocyte physiology

Availability

Mouse Genotype

Il4/Il13^tm3Anjm/Il4/Il13^tm3Anjm

Il4^tm1(CD2)Mmrs/Il4^tm1(CD2)Mmrs

Il4^tm1.1Wep/Il4^tm1.1Wep

Il4^tm1Cgn/Il4^tm1Cgn

Il4^tm1Kopf/Il4^tm1Kopf

Il4^tm1Nnt/Il4^tm1Nnt

Il4^tm1Rao/Il4^tm1Rao

Il4^tm2.1Kubo/Il4^tm2.1Kubo

Il4^tm2Nnt/Il4^tm2Nnt

Il4^tm1.1Wep/Il4⁺

Tg(KRT14-Il4)#Lsch/0

Tg(LckIl4)1315Dbl/0

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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